L-arginine
Intervention1 paper3 findingsPubChem 6322ChEBI 16467
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Human trial1
Outcomes
3Memory
upin humans1
1 study
Memory
upin humans1
L-arginine improves memory in humans.
Human trialin elderly patients with cognitive impairment6.4 g/day30 daysn = 35
Comparison of the Safety and Efficacy of Oral L-arginine for the Treatment of Cognitive Impairment in Older Adults: A Prospective, Randomized, Placebo-Controlled Pilot Study · Cureus · 20 Jul 2026
Attention
upin humans1
1 study
Attention
upin humans1
L-arginine improves attention in humans.
Human trialin elderly patients with cognitive impairment6.4 g/day30 daysn = 35
Comparison of the Safety and Efficacy of Oral L-arginine for the Treatment of Cognitive Impairment in Older Adults: A Prospective, Randomized, Placebo-Controlled Pilot Study · Cureus · 20 Jul 2026
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
L-arginine improves cognitive function in humans (37.5% vs. 5.3% (p=0.032)).
Human trialin elderly patients with cognitive impairment6.4 g/day30 daysn = 38
Comparison of the Safety and Efficacy of Oral L-arginine for the Treatment of Cognitive Impairment in Older Adults: A Prospective, Randomized, Placebo-Controlled Pilot Study · Cureus · 20 Jul 2026