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Istradefylline

Intervention

1 paper3 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: American Heart Association and 3 more
  • 3 of 3 findings with company ties
  • Animals1

Outcomes

3

Blood-brain barrier integrity

downin mice1

1 study

  1. Istradefylline protects against blood-brain barrier integrity in mice.

    “maintained blood-brain barrier integrity by maintaining the expression of tight junction proteins”

    Animalsin aged female 3xTg micebrainfemales

    Blockade of A2AR improved brain perfusion and cognitive function in a mouse model of Alzheimer's disease

    GeroScienceJan 22, 2025

Cognitive function

upin mice1

1 study

  1. Istradefylline improves cognitive function in mice.

    “preserved functional learning/memory”

    Animalsin aged female 3xTg micefemales

    Blockade of A2AR improved brain perfusion and cognitive function in a mouse model of Alzheimer's disease

    GeroScienceJan 22, 2025

Cerebral perfusion

upin mice1

1 study

  1. Istradefylline increases cerebral perfusion in mice.

    “modulation of A2AR signaling in aged female 3xTg increased cerebral perfusion by decreasing PRMT4 expression”

    Animalsin aged female 3xTg micebrainfemales

    Blockade of A2AR improved brain perfusion and cognitive function in a mouse model of Alzheimer's disease

    GeroScienceJan 22, 2025

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