Intensive titration program

Intensive titration program is associated with target dose achievement in humans (ARNi: 1% vs. 31%; MRA: 1% vs. 14%; BB: 3% vs. 5%).

“Target dose achievement improved across all drug classes between baseline and 3 months: ARNi (1% vs. 31%), MRA (1% vs. 14%), and BB (3% vs. 5%)”

HumansHeart failure with reduced ejection fraction3 monthsn = 64

Intensive titration for elderly patients with heart failure

Journal of geriatric cardiology : JGC·Sep 28, 2026

Intensive titration program is associated with quadruple therapy prescription in humans (33% prescribed quadruple therapy; 5% achieved ≥ 50% of target dose in each class).

“At 3 months, 33% of patients were prescribed quadruple therapy, with 5% achieving ≥ 50% of the recommended target dose in each drug class.”

HumansHeart failure with reduced ejection fraction3 months70% malesn = 64

Intensive titration for elderly patients with heart failure

Journal of geriatric cardiology : JGC·Sep 28, 2026