Intensive antihypertensive treatment
1 paper4 findings
- 1 lab in 2 countries
- Funders: Radboud Universitair Medisch Centrum and 1 more
- Human trial1
Outcomes
4Orthostatic hypotension
no changein humans1
1 study
Orthostatic hypotension
no changein humans1
Intensive antihypertensive treatment has no effect on orthostatic hypotension in humans (P ≥ 0.655).
“and the prevalence of OH and initial OH did not increase (P ≥ 0.655).”
Human trialfrail hypertensive patientsmedian 7-weekn = 14
GeroScienceMay 9, 2024
Cerebral autoregulation
no changein humans1
1 study
Cerebral autoregulation
no changein humans1
Intensive antihypertensive treatment has no effect on cerebral autoregulation in humans (P > 0.05).
“CA remained normal following AHT (P > 0.05)”
Human trialfrail hypertensive patientsmedian 7-weekn = 14
GeroScienceMay 9, 2024
Cerebral blood flow
no changein humans1
1 study
Cerebral blood flow
no changein humans1
Intensive antihypertensive treatment has no effect on cerebral blood flow in humans (95%CI: -2.7, 30.4).
“Non-inferiority was confirmed for the relative change in MCAv (95%CI: -2.7, 30.4).”
Human trialfrail hypertensive patientsmedian 7-weekn = 10
GeroScienceMay 9, 2024
Mean arterial pressure
downin humans1
1 study
Mean arterial pressure
downin humans1
Intensive antihypertensive treatment decreases mean arterial pressure in humans (-15 mmHg).
“Unattended mean arterial pressure decreased by 15 mmHg following AHT.”
Human trialfrail hypertensive patientsmedian 7-weekn = 14
GeroScienceMay 9, 2024