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Inhibition of ifnγ-signaling

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Funders: Alexander von Humboldt-Stiftung and 2 more
  • Animals1

Outcomes

2

Immune response

downin animals1

1 study

  1. Inhibition of ifnγ-signaling decreases immune response.

    “systemic inhibition of IFNγ-signaling completely reverses these aging phenotypes”

    Animalsintestinal epithelium

    IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

    Nature communicationsSep 30, 2023

More on Immune response

Intestinal epithelial regeneration

upin animals1

1 study

  1. Inhibition of ifnγ-signaling improves intestinal epithelial regeneration.

    “reinstalls regenerative capacity of the aged intestinal epithelium.”

    Animalsintestinal epithelium

    IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

    Nature communicationsSep 30, 2023

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