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INHBE-00003

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 3 of 3 findings with company ties
  • Animals1

Outcomes

3

Inflammation

downin mice1−68%

1 study

  1. INHBE-00003 decreases inflammation in mice (up to 68%).

    “Infiltration of activated macrophages in visceral adipose tissue was also decreased by up to 68% compared with controls.”

    Animalsin diet-induced obesity (DIO) micevisceral adipose tissue28 days

    MON-715 Silencing Hepatokine Activin E Production in Mice Recapitulates Human Genetic Data and Demonstrates Improved Healthy Weight Loss Profile

    ENDO 2025 abstract22 Oct 2025

More on Inflammation

Visceral adipose mass

downin mice1−40%

1 study

  1. INHBE-00003 decreases visceral adipose mass in mice (-40%).

    “had 40% less diet-induced visceral adipose mass accumulation, and demonstrated 43% less diet-induced adipocyte enlargement than PBS-treated mice”

    Animalsin diet-induced obesity (DIO) micevisceral adipose tissue28 days

    MON-715 Silencing Hepatokine Activin E Production in Mice Recapitulates Human Genetic Data and Demonstrates Improved Healthy Weight Loss Profile

    ENDO 2025 abstract22 Oct 2025

Body weight

downin mice1−9%

1 study

  1. INHBE-00003 decreases body weight in mice (-9%).

    “By 28 days after a single dose of INHBE-00003, DIO mice weighed 9% less, had 40% less diet-induced visceral adipose mass accumulation”

    Animalsin diet-induced obesity (DIO) mice28 days

    MON-715 Silencing Hepatokine Activin E Production in Mice Recapitulates Human Genetic Data and Demonstrates Improved Healthy Weight Loss Profile

    ENDO 2025 abstract22 Oct 2025

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