Delapril
- 1 lab in 1 country
- 3 of 3 findings with company ties
- Animals1
Outcomes
3Heart weight/body weight ratio
downin rats1
1 study
Heart weight/body weight ratio
downin rats1
Delapril decreases heart weight/body weight ratio in rats (p < 0.001).
“All treatments induced a highly significant (p < 0.001) reduction of heart weight/body weight and kidney weight/body weight ratios.”
Animalsin salt-loaded stroke-prone spontaneously hypertensive rats
Arzneimittel-Forschung1 Nov 1998
Cerebrovascular lesions
downin rats1
1 study
Cerebrovascular lesions
downin rats1
Delapril prevents cerebrovascular lesions in rats (0% vs 56% in surviving controls).
“no death and no cerebral lesions were observed in animals drinking saline, to which delapril, indapamide and their combination had been added, up to the end of treatment.”
Animalsin salt-loaded stroke-prone spontaneously hypertensive ratsdrinking saline solution31 weeks of treatment and up to 8 weeks thereafter
Arzneimittel-Forschung1 Nov 1998
Mortality
downin rats1
1 study
Mortality
downin rats1
Delapril decreases mortality in rats (0 deaths vs ~50% in controls).
“no death and no cerebral lesions were observed in animals drinking saline, to which delapril, indapamide and their combination had been added, up to the end of treatment.”
Animalsin salt-loaded stroke-prone spontaneously hypertensive ratsdrinking saline solution31 weeks of treatment and up to 8 weeks thereafter
Arzneimittel-Forschung1 Nov 1998