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Hyperosmolar lubricant

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Outcomes

2

Vaginal microbiota stability

downin humans1

1 study

  1. Hyperosmolar lubricant decreases vaginal microbiota stability in humans.

    “Our findings suggest that vaginal microbiota stability decreased after TVUS.”

    Human trialvaginafemalesn = 104

    THE VAGINAL MICROBIOTA BEFORE AND AFTER HYPEROSMOLAR LUBRICANT USE IN PRE-, PERI-, AND POSTMENOPAUSAL WOMEN

    GSA 2024 abstract31 Dec 2024

Lactobacillus-dominated microbiota

downin humans1

1 study

  1. Hyperosmolar lubricant decreases Lactobacillus-dominated microbiota in humans (aOR 3.22, 95% CI 1.16-8.98).

    “Specifically, peri/postmenopausal women (N=19, aOR:3.22, 95% CI:1.16-8.98) and those with a history of bacterial vaginosis (N=58, aOR:1.73, 95% CI:1.10-2.72) were more prone to decreases in Lactobacillus-dominant microbiota after TVUS.”

    Human trialin peri/postmenopausal womenvaginafemalesn = 19

    THE VAGINAL MICROBIOTA BEFORE AND AFTER HYPEROSMOLAR LUBRICANT USE IN PRE-, PERI-, AND POSTMENOPAUSAL WOMEN

    GSA 2024 abstract31 Dec 2024

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