Human umbilical cord mesenchymal stem cell exosomes

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Animals1

Outcomes

TLR4/MyD88/NF-κB signaling

downin mice1

1 study

Human umbilical cord mesenchymal stem cell exosomes inhibit TLR4/MyD88/NF-κB signaling in mice.
“inhibited activation of the TLR4/MyD88/NF-κB signaling pathway in mouse hippocampal tissue (P<0.05).”
Animalssevoflurane-induced postoperative cognitive dysfunctionhippocampus
Effects and mechanisms of action of hUMSCs-Exos on sevoflurane-induced postoperative cognitive dysfunction and synaptic plasticity impairment in aged mice
Chinese Journal of Gerontology8 Oct 2026

Hippocampal synaptic plasticity

upin mice1

1 study

Human umbilical cord mesenchymal stem cell exosomes improve hippocampal synaptic plasticity in mice.
“Administration of hUMSCs-Exos significantly ameliorated sevoflurane-induced cognitive dysfunction, hippocampal neuronal injury, and hippocampal synaptic plasticity impairment in aged mice”
Animalssevoflurane-induced postoperative cognitive dysfunctionhippocampus
Effects and mechanisms of action of hUMSCs-Exos on sevoflurane-induced postoperative cognitive dysfunction and synaptic plasticity impairment in aged mice
Chinese Journal of Gerontology8 Oct 2026

Hippocampal neuronal injury

downin mice1

1 study

Human umbilical cord mesenchymal stem cell exosomes decrease hippocampal neuronal injury in mice.
“Administration of hUMSCs-Exos significantly ameliorated sevoflurane-induced cognitive dysfunction, hippocampal neuronal injury, and hippocampal synaptic plasticity impairment in aged mice”
Animalssevoflurane-induced postoperative cognitive dysfunctionhippocampus
Effects and mechanisms of action of hUMSCs-Exos on sevoflurane-induced postoperative cognitive dysfunction and synaptic plasticity impairment in aged mice
Chinese Journal of Gerontology8 Oct 2026

Cognitive function

upin mice1

1 study

Human umbilical cord mesenchymal stem cell exosomes improve cognitive function in mice.
“Administration of hUMSCs-Exos significantly ameliorated sevoflurane-induced cognitive dysfunction, hippocampal neuronal injury, and hippocampal synaptic plasticity impairment in aged mice”
Animalssevoflurane-induced postoperative cognitive dysfunction
Effects and mechanisms of action of hUMSCs-Exos on sevoflurane-induced postoperative cognitive dysfunction and synaptic plasticity impairment in aged mice
Chinese Journal of Gerontology8 Oct 2026

Latest

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Chinese Journal of GerontologyYesterday

Effects and mechanisms of action of hUMSCs-Exos on sevoflurane-induced postoperative cognitive dysfunction and synaptic plasticity impairment in aged mice

Experiments in 10 miceInterventions

Paper

Human umbilical cord mesenchymal stem cell exosomes

Outcomes

Latest

Effects and mechanisms of action of hUMSCs-Exos on sevoflurane-induced postoperative cognitive dysfunction and synaptic plasticity impairment in aged mice

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