Human induced pluripotent stem cell-derived mesenchymal progenitor cells

Intervention

1 paper3 findings

  • 1 lab in 1 country
  • Funders: Japan Science and Technology Agency and 3 more
  • Animals1

Outcomes

3

Anti-inflammatory cytokines

upin mice1

1 study
  1. Human induced pluripotent stem cell-derived mesenchymal progenitor cells increase anti-inflammatory cytokines in mice.

    “higher expression of anti-inflammatory cytokines than fibroblast tissues.”

    Animalscompared to fibroblast tissuessubcutaneous

    Human iPSC-derived mesenchymal progenitor cell sheets promote tissue formation after xenotransplantation

    iScience11 Aug 2026

More on Anti-inflammatory cytokines

Immune cell infiltration

downin mice1

1 study
  1. Human induced pluripotent stem cell-derived mesenchymal progenitor cells decrease immune cell infiltration in mice.

    “hiPS-MPC-derived tissues exhibited reduced immune cell infiltration and higher expression of anti-inflammatory cytokines than fibroblast tissues.”

    Animalscompared to fibroblast tissuessubcutaneous

    Human iPSC-derived mesenchymal progenitor cell sheets promote tissue formation after xenotransplantation

    iScience11 Aug 2026

More on Immune cell infiltration

Vascularized tissue-like structures

upin mice1

1 study
  1. Human induced pluripotent stem cell-derived mesenchymal progenitor cells induce vascularized tissue-like structures in mice.

    “By day 7, mouse MSC and hiPS-MPC sheets formed organized vascularized tissue-like structures”

    Animalsxenotransplantation into immunocompetent micesubcutaneousday 7

    Human iPSC-derived mesenchymal progenitor cell sheets promote tissue formation after xenotransplantation

    iScience11 Aug 2026

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