Human induced neuron transplantation

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Associations

Afferent synaptic connectivity with host circuits

upin mice1

1 study

Human induced neuron transplantation is associated with afferent synaptic connectivity with host circuits in mice.
AnimalsTransplantation into immunodeficient mouse cortex3D cultures of reprogrammed human induced neuronsbrain
Reprogrammed human neurons survive and mature in mice
Neurobiology of disease9 Oct 2026

Neuronal maturation

upin mice1

1 study

Human induced neuron transplantation is associated with neuronal maturation in mice.
AnimalsTransplantation into immunodeficient mouse cortex3D cultures of reprogrammed human induced neuronsbrain
Reprogrammed human neurons survive and mature in mice
Neurobiology of disease9 Oct 2026

Graft cell migration into connected brain regions

upin mice1

1 study

Human induced neuron transplantation is associated with graft cell migration into connected brain regions in mice.
AnimalsTransplantation into immunodeficient mouse cortex3D cultures of reprogrammed human induced neuronsbrain
Reprogrammed human neurons survive and mature in mice
Neurobiology of disease9 Oct 2026

Graft cell survival

upin mice1

1 study

Human induced neuron transplantation is associated with graft cell survival in mice (Survival up to 5 months, with a proportion remaining up to 10 months).
AnimalsTransplantation into immunodeficient mice3D cultures of reprogrammed human induced neuronscerebral cortexUp to 10 months post-transplantation
Reprogrammed human neurons survive and mature in mice
Neurobiology of disease9 Oct 2026

Latest

1 in 12 months

Neurobiology of Disease2 h

Reprogrammed human neurons survive and mature in mice

Transplanted human neurons survived for up to 5 months, with a proportion remaining up to 10 months, in mice lacking normal immune defences.Transplanted human neurons survived for up to 5 months, with a proportion remaining up to 10 months, in mice lacking normal immune defences.

Experiments in miceInterventions

Paper

Human induced neuron transplantation

Associations

Latest

Reprogrammed human neurons survive and mature in mice

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