Human immunodeficiency virus 1
1 paper3 findings
- 1 lab in 1 country
- Funders: National Institute of Allergy and Infectious Diseases and 5 more
- Animals1
Outcomes
2LMNA
downin mice1
1 study
LMNA
downin mice1
Human immunodeficiency virus 1 decreases LMNA in mice.
“downregulated LMNA and CLU were identified as age-associated genes tied to HIV-1 infection.”
Animalschronically HIV-1-infected CD34-NSG humanized micebrain40 weeks
Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice
Pharmaceuticals (Basel, Switzerland)23 Jan 2024
C1QA
upin mice1
1 study
C1QA
upin mice1
Human immunodeficiency virus 1 increases C1QA in mice.
“Upregulated C1QA, CD163, and CXCL16 and downregulated LMNA and CLU were identified as age-associated genes tied to HIV-1 infection.”
Animalschronically HIV-1-infected CD34-NSG humanized micebrain40 weeks
Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice
Pharmaceuticals (Basel, Switzerland)23 Jan 2024
Associations
1CD4+ T cell count
downin mice1
1 study
CD4+ T cell count
downin mice1
Human immunodeficiency virus 1 is associated with CD4+ T cell count in mice.
“CD4+ T cell decline was associated with viral level and age.”
Animalschronically HIV-1-infected CD34-NSG humanized mice40 weeks
Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice
Pharmaceuticals (Basel, Switzerland)23 Jan 2024