High tryptophan diet
High tryptophan diet has been studied in 2 papers since 2016: none in people yet, 2 in animals. The research so far is in animals. The newest paper, May 8, 2021: “A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice”.
2 papers study it3 findingsUpdated
See all 2 papers on high tryptophan diet
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: Università di Catania
- Animals2
What did studies of high tryptophan diet find?
3Studies of high tryptophan diet measured 3 outcomes: CREB phosphorylation, TUNEL-positive cells and passive avoidance behavior.
CREB phosphorylation
upin rats1
1 study
CREB phosphorylation
upin rats1
High tryptophan diet increases CREB phosphorylation in rats (age-induced inhibition).
“high TrP diet partially rescued the age-induced inhibition of hippocampal CREB phosphorylation.”
Animalsage-induced inhibitionhippocampus1 month
Brain research bulletin
TUNEL-positive cells
downin rats1
1 study
TUNEL-positive cells
downin rats1
High tryptophan diet decreases TUNEL-positive cells in rats.
“high TrP diet improves PA behaviour of aged rats and this correlated with a decrease of TUNEL positive cells in all hippocampal regions tested”
Animalshippocampus: CA1, CA2, CA3, dentate gyrus1 month
Brain research bulletin
Passive avoidance behavior
upin rats1
1 study
Passive avoidance behavior
upin rats1
High tryptophan diet improves passive avoidance behavior in rats.
“we found that high TrP diet improves PA behaviour of aged rats”
Animals1 month
Brain research bulletin