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High pressure gradient driving venous return

High pressure gradient driving venous return has been studied in 1 paper since 2023: 1 observational study in people. The newest paper, Nov 9, 2023: “Sex-Specific Limitation of Cardiac Capacity During the Adult Life Span: Return to Fundamental Structure and Function”.

Intervention

1 paper studies it3 findingsUpdated

“In young individuals, "high"-PG increased exercise LVEDV and SV in men (p ≤ .002), but not in women (p ≥ .562), relative to "low"-PG (control condition).”
Sex-Specific Limitation of Cardiac Capacity During the Adult Life Span: Return to Fundamental Structure and FunctionThe journals of gerontology. Series A, Biological sciences and medical sciences2023doi:10.1093/gerona/glad255

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Humans1

What did studies of High pressure gradient driving venous return find?

2

Studies of High pressure gradient driving venous return measured 2 outcomes; the most studied are left ventricular end-diastolic volume (1 study) and left ventricular diastolic function (1).

Left ventricular end-diastolic volume

no changein humans1upin humans1

1 study

  1. High pressure gradient driving venous return has no effect on left ventricular end-diastolic volume in humans.

    “In young individuals, "high"-PG increased exercise LVEDV and SV in men (p ≤ .002), but not in women (p ≥ .562), relative to "low"-PG (control condition).”

    Human trialrelative to low-PG (control condition)females

    Sex-Specific Limitation of Cardiac Capacity During the Adult Life Span: Return to Fundamental Structure and Function

    The journals of gerontology. Series A, Biological sciences and medical sciences

  2. High pressure gradient driving venous return increases left ventricular end-diastolic volume in humans.

    “In young individuals, "high"-PG increased exercise LVEDV and SV in men (p ≤ .002), but not in women (p ≥ .562), relative to "low"-PG (control condition).”

    Human trialrelative to low-PG (control condition)males

    Sex-Specific Limitation of Cardiac Capacity During the Adult Life Span: Return to Fundamental Structure and Function

    The journals of gerontology. Series A, Biological sciences and medical sciences

More on Left ventricular end-diastolic volume

Left ventricular diastolic function

downin humans1

1 study

  1. High pressure gradient driving venous return decreases left ventricular diastolic function in humans.

    “In older individuals, "high"-PG did not modify exercise cardiac volumes and reduced LV diastolic function (p ≤ .049).”

    Human trial

    Sex-Specific Limitation of Cardiac Capacity During the Adult Life Span: Return to Fundamental Structure and Function

    The journals of gerontology. Series A, Biological sciences and medical sciences

More on Left ventricular diastolic function

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