Hcy-nbd

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Key Research and Development Program of China and 2 more

Animals1

Outcomes

Vascular calcification

downin mice1downin mouse cells1

1 study

Hcy-nbd decreases vascular calcification in mice.
“in vivo administration of HCY-NBD in db/db mice increases GSTM2 levels and mitigates senescence and calcification in the thoracic aorta.”
Animalsin db/db micethoracic aorta
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification
Redox biology27 Jan 2026
Hcy-nbd inhibits vascular calcification in mouse cells.
“HCY-NBD upregulates GSTM2 and inhibits HG-induced senescence and calcification in vascular endothelial cells.”
Cellshigh-glucose-induced
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification
Redox biology27 Jan 2026

Cellular senescence

downin mice1downin mouse cells1

1 study

Hcy-nbd decreases cellular senescence in mice.
“in vivo administration of HCY-NBD in db/db mice increases GSTM2 levels and mitigates senescence and calcification in the thoracic aorta.”
Animalsin db/db micethoracic aorta
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification
Redox biology27 Jan 2026
Hcy-nbd inhibits cellular senescence in mouse cells.
“HCY-NBD upregulates GSTM2 and inhibits HG-induced senescence and calcification in vascular endothelial cells.”
Cellshigh-glucose-induced
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification
Redox biology27 Jan 2026

Latest

1 in 12 months

Redox Biology5 Feb

Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification

Experiments in miceVascular calcification

Paper

Hcy-nbd

Outcomes

Latest

Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification

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