Guanidinoacetic acid
Intervention1 paper3 findingsPubChem 763ChEBI 16344
- Human trial1
Outcomes
3Myostatin
downin humans1Moderate certainty
1 study
Myostatin
downin humans1Moderate certainty
Guanidinoacetic acid decreases myostatin in humans.
Human trial8 wkn = 21
Comparative Effects of Guanidinoacetic Acid and Creatine on Body Composition, Muscle Strength, and Protein Metabolism Biomarkers in Older Adults: A Randomized Exploratory Pilot Trial · Journal of nutritional science and vitaminology · 1 Jan 2026
Muscle mass
upin humans1Moderate certainty
1 study
Muscle mass
upin humans1Moderate certainty
Guanidinoacetic acid increases muscle mass in humans.
Human trialwithout structured exercise2.0 g/d8 wkn = 11
Comparative Effects of Guanidinoacetic Acid and Creatine on Body Composition, Muscle Strength, and Protein Metabolism Biomarkers in Older Adults: A Randomized Exploratory Pilot Trial · Journal of nutritional science and vitaminology · 1 Jan 2026
Handgrip strength
upin humans1Moderate certainty
1 study
Handgrip strength
upin humans1Moderate certainty
Guanidinoacetic acid improves handgrip strength in humans (g=0.91, 95% CI: 0.00 to 1.81).
Human trialwithout structured exercise2.0 g/d8 wkn = 11
Comparative Effects of Guanidinoacetic Acid and Creatine on Body Composition, Muscle Strength, and Protein Metabolism Biomarkers in Older Adults: A Randomized Exploratory Pilot Trial · Journal of nutritional science and vitaminology · 1 Jan 2026