General anesthesia + peripheral nerve block
General anesthesia + peripheral nerve block has been studied in 1 paper since 2026: 1 observational study in people; 1 in the past year. The newest paper, Oct 21, 2026: “Association of peripheral nerve block plus general anesthesia with MMSE-Defined early postoperative cognitive decline in older orthopedic patients: A prospective observational pilot study”.
1 paper studies it4 findingsUpdated
1 new paper in 30 daysSee all 1
“POD7 MMSE-defined early postoperative cognitive decline occurred in 5/49 GA patients (10.2%) and 0/40 GA+Block patients.”
None of its findings points the other way.
- 1 lab in 1 country
- Humans1
What did studies of General anesthesia + peripheral nerve block find?
3Studies of General anesthesia + peripheral nerve block measured 3 outcomes; the most studied are postoperative neuronal/stress biomarkers (1 study), cerebral oxygenation (1) and cognitive recovery trajectories (1).
Postoperative neuronal/stress biomarkers
no changein humans1
1 study
Postoperative neuronal/stress biomarkers
no changein humans1
General anesthesia + peripheral nerve block has no effect on postoperative neuronal/stress biomarkers in humans.
“postoperative biomarker changes did not differ significantly.”
HumansElective orthopedic surgery; compared with general anesthesia alonen = 89
Science progress
Cerebral oxygenation
no changein humans1
1 study
Cerebral oxygenation
no changein humans1
General anesthesia + peripheral nerve block has no effect on cerebral oxygenation in humans.
“Cerebral oxygenation remained stable and comparable”
HumansElective orthopedic surgery; compared with general anesthesia alonebrainn = 89
Science progress
Cognitive recovery trajectories
no changein humans1
1 study
Cognitive recovery trajectories
no changein humans1
General anesthesia + peripheral nerve block has no effect on cognitive recovery trajectories in humans.
“Cognitive recovery slopes were similar between groups (p=0.79).”
HumansElective orthopedic surgery; compared with general anesthesia aloneThrough postoperative day 7n = 89
Science progress
What is General anesthesia + peripheral nerve block linked with?
1Studies link General anesthesia + peripheral nerve block with 1 measure, most often POD7 MMSE-defined early postoperative cognitive decline (1 study).
POD7 MMSE-defined early postoperative cognitive decline
downin humans1RR 0.11
1 study
POD7 MMSE-defined early postoperative cognitive decline
downin humans1RR 0.11
General anesthesia + peripheral nerve block is associated with POD7 MMSE-defined early postoperative cognitive decline in humans (0/40 versus 5/49 (10.2%); absolute risk difference −10.2 percentage points; corrected RR 0.11 (95% CI 0.006–1.95)).
“POD7 MMSE-defined early postoperative cognitive decline occurred in 5/49 GA patients (10.2%) and 0/40 GA+Block patients.”
HumansElective orthopedic surgery; compared with general anesthesia alonePostoperative day 7n = 89
Science progress