Fullerene C60

Intervention

2 papers study it1 more mentions it3 findings

PubChemChEBIMeSH

  • 2 independent labs in 2 countries
  • Animals2

Outcomes

2

Lifespan

upin mice1upin rats1

2 studies
  1. Fullerene C60 extends lifespan in mice.

    “Treatment of mice with C60 fullerenes resulted in an increased lifespan of males and females compared with the olive oil-treated animals.”

    Animalsdissolved in virgin olive oil, compared with olive oil-treated animalsdissolved in virgin olive oil7 months

    Effect of Long-Term Treatment with C₆₀ Fullerenes on the Lifespan and Health Status of CBA/Ca Mice

    Rejuvenation researchMay 19, 2021

  2. Fullerene C60 extends lifespan in rats (almost doubles).

    “oral administration of C(60) dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan”

    Animalsdissolved in olive oil (0.8 mg/ml)1.7 mg/kg

    The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

    BiomaterialsApr 10, 2012

Oxidative stress and ROS signaling

downin rats1

1 study
  1. Fullerene C60 decreases oxidative stress and ROS signaling in rats.

    “effects of C(60)-olive oil solutions in an experimental model of CCl(4) intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress”

    Animalsexperimental model of CCl(4) intoxicationdissolved in olive oil

    The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

    BiomaterialsApr 10, 2012

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