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Foxp3 inhibition

Intervention

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute of Allergy and Infectious Diseases and 2 more
  • 1 of 1 finding with company ties
  • Animals1

Outcomes

1

Multiple sclerosis

downin mice1

1 study

  1. Foxp3 inhibition decreases multiple sclerosis in mice.

    “Transiently inhibiting FoxP3 or depleting pTreg cells partially corrected Treg distribution and restored the Treg/Teff balance in the aged inflamed CNS, thereby ameliorating the disease in the aged EAE mice.”

    Animalsin aged EAE mice

    Accumulation of pTreg cells is detrimental in late-onset (aged) mouse model of multiple sclerosis

    Aging cellMay 26, 2022

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