First generation senolytics
First generation senolytics has been studied in 1 paper since 2023: none in people yet, 1 in cells. No study of it in people or animals has been published yet. The newest paper, Dec 11, 2023: “A versatile method for the identification of senolytic compounds”.
1 paper studies it1 findingUpdated
See all 1 papers on first generation senolytics
At a glance
The findings reach cells, none yet in people. 1 lab in 1 country.
- 1 lab in 1 country
- Funders: Karolinska Institutet and 1 more
- 1 of 1 finding with company ties
- Cells1
What did studies of first generation senolytics find?
1Studies of first generation senolytics measured one outcome, RFP+ senescent cell nuclei count.
RFP+ senescent cell nuclei count
downin cells1
1 study
RFP+ senescent cell nuclei count
downin cells1
First generation senolytics decrease RFP+ senescent cell nuclei count in quiescent-senescent co-cultures with H2B-GFP and H2B-RFP tagging.
“first generation senolytics were effective in reducing the number of RFP+ nuclei leaving the count of GFP+ nuclei unaffected”
Cellsin quiescent-senescent co-cultures with H2B-GFP and H2B-RFP tagging
A versatile method for the identification of senolytic compounds
Cell stress