Fda-approved drugs
Intervention1 paper3 findings
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Model organisms1
Outcomes
3Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Fda-approved drugs decrease cellular senescence in human cells.
CellsSeveral compounds identified in the screen
Automated screen finds drugs that help worms resist heat · bioRxiv : the preprint server for biology · 10 Aug 2026 · Preprint
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Fda-approved drugs extend lifespan in worms.
Model organismsMany of the compounds identified as increasing heat stress resistance
Automated screen finds drugs that help worms resist heat · bioRxiv : the preprint server for biology · 10 Aug 2026 · Preprint
Heat stress resistance
upin worms1
1 study
Heat stress resistance
upin worms1
Fda-approved drugs increase heat stress resistance in worms.
Model organisms31 compounds identified in a screen of 2,782 FDA-approved drugs
Automated screen finds drugs that help worms resist heat · bioRxiv : the preprint server for biology · 10 Aug 2026 · Preprint
Latest
1Automated screen finds drugs that help worms resist heat
A screen of 2,782 drugs approved by US regulators identified 31 that reproducibly increased heat-stress resistance in worms.A screen of 2,782 drugs approved by US regulators identified 31 that reproducibly increased heat-stress resistance in worms.