Fagopyrum tataricum

Fagopyrum tataricum has been studied in 2 papers since 2022: 1 trial in people, 1 in animals; 1 in the past year. The newest story, Nov 4, 2026: “Buckwheat powder did not beat placebo on main cognition measure”.

Intervention

2 papers study it4 findingsUpdated Nov 4, 2026

1 new paper in 30 daysSee all 2 papers on fagopyrum tataricum

At a glance

The findings reach people, from one lab or study. 1 lab.

“the rate of change in the primary outcome, PROMIS Cognitive Function, did not differ between arms”

Himalayan Tartary Buckwheat Sprout Powder, Perceived Cognitive Abilities, and Objective Processing Speed: A Randomized, Double-Blind, Placebo-Controlled TrialmedRxiv2026doi:10.64898/2026.11.03.26367186

None of its findings points the other way.

1 lab

4 of 4 findings with company ties

Human trial1
Animals1

Studies in people

1 study gave fagopyrum tataricum to people and measured what changed.

What changed	Design	People	Source
no change: Has no effect on PROMIS Cognitive FunctionRate-of-change contrast = 0.03, 95% CI -0.07 to 0.13; p = .59 up: Increases meaningful improvement in PROMIS Cognitive Abilities68.7% vs 52.5%; RR = 1.32, 95% CI 1.10 to 1.59; p = .003 down: Decreases reaction time on Flanker and Stroop tasks	Randomized trial12 weeks	662 peopleadultsSelf-reported cognitive difficulties	medRxiv, Nov 4, 2026

no change: Has no effect on PROMIS Cognitive FunctionRate-of-change contrast = 0.03, 95% CI -0.07 to 0.13; p = .59

up: Increases meaningful improvement in PROMIS Cognitive Abilities68.7% vs 52.5%; RR = 1.32, 95% CI 1.10 to 1.59; p = .003

down: Decreases reaction time on Flanker and Stroop tasks

Randomized trial12 weeks

662 peopleadultsSelf-reported cognitive difficulties

medRxiv, Nov 4, 2026

What did studies of fagopyrum tataricum find?

Studies of fagopyrum tataricum measured 4 outcomes; the most studied are side-effect rates (1 study), reaction time on Flanker and Stroop tasks (1) and meaningful improvement in PROMIS Cognitive Abilities (1).

Side-effect rates

no changein humans1

1 study

Fagopyrum tataricum showed no clear effect on side-effect rates in humans (self-reported cognitive difficulties).
“Side-effect rates were similar between arms.”
Human trialself-reported cognitive difficultiessprout powder18 g per day12 weeks
Buckwheat powder did not beat placebo on main cognition measure
medRxivNov 4, 2026Preprint

Reaction time on Flanker and Stroop tasks

downin humans1

1 study

Fagopyrum tataricum decreases reaction time on Flanker and Stroop tasks in humans (exploratory computerized testing in adults with self-reported cognitive difficulties).
“HTB participants had faster reaction times on the Flanker and Stroop tasks, without loss of accuracy.”
Human trialexploratory computerized testing in adults with self-reported cognitive difficultiessprout powder18 g per day12 weeksn = 512
Buckwheat powder did not beat placebo on main cognition measure
medRxivNov 4, 2026Preprint

Meaningful improvement in PROMIS Cognitive Abilities

upin humans1RR 1.32

1 study

Fagopyrum tataricum increases meaningful improvement in PROMIS Cognitive Abilities in humans (participants with final-week data and self-reported cognitive difficulties) (68.7% vs 52.5%; RR = 1.32, 95% CI 1.10 to 1.59; p = .003).
“more HTB than placebo participants achieved a meaningful ([≥]0.5 SD) improvement in Cognitive Abilities”
Human trialparticipants with final-week data and self-reported cognitive difficultiessprout powder18 g per day12 weeksn = 296
Buckwheat powder did not beat placebo on main cognition measure
medRxivNov 4, 2026Preprint

PROMIS Cognitive Function

no changein humans1

1 study

Fagopyrum tataricum showed no clear effect on PROMIS Cognitive Function in humans (self-reported cognitive difficulties) (Rate-of-change contrast = 0.03, 95% CI -0.07 to 0.13; p = .59).
“the rate of change in the primary outcome, PROMIS Cognitive Function, did not differ between arms”
Human trialself-reported cognitive difficultiessprout powder18 g per day12 weeksn = 662
Buckwheat powder did not beat placebo on main cognition measure
medRxivNov 4, 2026Preprint

Latest

1 paper in 12 months

medRxivNov 4

Buckwheat powder did not beat placebo on main cognition measure

The main self-rated cognitive-function score changed at similar rates with buckwheat and placebo, with a difference of 0.03 during the 12-week trial.The main self-rated cognitive-function score changed at similar rates with buckwheat and placebo, with a difference of 0.03 during the 12-week trial.

Preprint: randomized trial · 662 peopleInterventions

Paper

NutrientsJul 10

Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice

Experiments in miceCognitive decline

Paper