Headache
Combined hormone therapy linked to worsening headaches
Among women with migraine histories, combined therapy was linked to 1.53 times the risk of worsening headaches over one year compared with placebo.Among women with migraine histories, combined therapy was linked to 1.53 times the risk of worsening headaches over one year compared with placebo.
Randomized trial · 22,876 peopleHeadache
Who was studied22,876 postmenopausal women, 1-year follow-up, against placebo
What changedHeadaches worsened more often with combined hormone therapy than placebo (adjusted risk ratio 1.18)
The catchThe four-point headache scale could miss subtle changes in participants with consistently severe headaches