Energy-reduced Mediterranean diet plus physical activity
Energy-reduced Mediterranean diet plus physical activity has been studied in 1 paper since 2025: 1 trial in people. The newest paper, Apr 1, 2025: “Mediterranean Diet, Physical Activity, and Bone Health in Older Adults: A Secondary Analysis of a Randomized Clinical Trial”.
1 paper studies it5 findingsUpdated
See all 1 papers on energy-reduced Mediterranean diet plus physical activity
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country.
“Significant differences in mean changes between groups were observed, with an overall 3-year intervention increase in the intervention group (n = 460) compared with the control group (n = 464) in lumbar spine (L1-L4) BMD”
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca and others
- 5 of 5 findings with company ties
- Human trial1
Studies in people
1 study gave energy-reduced Mediterranean diet plus physical activity to people and measured what changed.
| What changed | Design | People | Source |
|---|---|---|---|
up: Increases lumbar spine bone mineral density no change: Has no effect on osteopenia down: Decreases body weight–2.2 kg [95% CI, –2.7 to –1.6 kg] after 3 years | Randomized trial3 years | 924 people454 women (49.1%) and 470 men (50.9%)mean (SD) 65.1 (5.0) yearsCommunity-dwelling adults (aged 55-75 years) with overweight or obesity who met at least 3 criteria for metabolic syndrome | JAMA network open, Apr 1, 2025 |
What did studies of energy-reduced Mediterranean diet plus physical activity find?
4Studies of energy-reduced Mediterranean diet plus physical activity measured 4 outcomes; the most studied are lumbar spine bone mineral density (1 study), body weight (1) and osteopenia (1).
Lumbar spine bone mineral density
upin humans1
1 study
Lumbar spine bone mineral density
upin humans1
Energy-reduced Mediterranean diet plus physical activity increases lumbar spine bone mineral density in humans.
“An overall 3-year intervention increase was observed for the intervention group compared with the control group for lumbar spine (L1-L4) BMD in the overall population”
Human triallumbar spine3 yearsn = 924
JAMA network open
Energy-reduced Mediterranean diet plus physical activity increases lumbar spine bone mineral density in humans (metabolic syndrome and overweight or obesity) (0.9 (95% CI, 0.1-1.8) g/cm2 after 3 years; overall P = .05).
“Significant differences in mean changes between groups were observed, with an overall 3-year intervention increase in the intervention group (n = 460) compared with the control group (n = 464) in lumbar spine (L1-L4) BMD”
Human trialmetabolic syndrome and overweight or obesityenergy-reduced Mediterranean diet and increased physical activity3 yearsn = 924
JAMA network open
Body weight
downin humans1
1 study
Body weight
downin humans1
Energy-reduced Mediterranean diet plus physical activity decreases body weight in humans (–2.2 kg [95% CI, –2.7 to –1.6 kg] after 3 years).
“Overall 3-year differences in changes in total body weight between groups were significant”
Human trial3 yearsn = 924
JAMA network open
Osteopenia
no changein humans1
1 study
Osteopenia
no changein humans1
Energy-reduced Mediterranean diet plus physical activity showed no clear effect on osteopenia in humans.
“Moreover, no overall intervention group effect on low BMD prevalence was shown over 3 years of follow-up ( and eTable 4 in ).”
Human trial3 yearsn = 924
JAMA network open
Bone mineral content
no changein humans1
1 study
Bone mineral content
no changein humans1
Energy-reduced Mediterranean diet plus physical activity showed no clear effect on bone mineral content in humans (metabolic syndrome and overweight or obesity).
“No overall 3-year intervention effect on total BMC and low BMD prevalence was observed.”
Human trialmetabolic syndrome and overweight or obesityenergy-reduced Mediterranean diet and increased physical activity3 yearsn = 924
JAMA network open