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Elevated pulse pressure

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 1 more
  • Humans1

Associations

2

Mean diffusivity

upin humans1

1 study

  1. Elevated pulse pressure is associated with mean diffusivity in humans.

    “elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD).”

    Humanswhite mattern = 144

    Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism8 Dec 2017

More on Mean diffusivity

Fractional anisotropy

downin humans1

1 study

  1. Elevated pulse pressure is associated with fractional anisotropy in humans.

    “elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD).”

    Humanswhite mattern = 144

    Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism8 Dec 2017

More on Fractional anisotropy

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