DORA-12
DORA-12 has been studied in 1 paper since 2023: none in people yet, 1 in animals. The research so far is in animals. The newest paper, May 25, 2023: “Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy”.
1 paper studies it3 findingsUpdated
- 1 lab in 1 country
- Funders: Alzheimer's Association and 4 more
- Animals1
What did studies of DORA-12 find?
3Studies of DORA-12 measured 3 outcomes; the most studied are REM sleep behavior disorder (1 study), sleep spindle density (1) and sleep duration (1).
REM sleep behavior disorder
downin mice1
1 study
REM sleep behavior disorder
downin mice1
DORA-12 decreases REM sleep behavior disorder in mice.
“We observed a significant effect of DORA-12 on objective measures of RBD”
Animalsin aged PS19 mice
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sleep spindle density
upin mice1
1 study
Sleep spindle density
upin mice1
DORA-12 increases sleep spindle density in mice.
“increased spindle density, spindle duration, and SO density without change to spindle-SO coupling”
Animalsin aged PS19 mice
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sleep duration
upin mice1
1 study
Sleep duration
upin mice1
DORA-12 increases sleep duration in mice.
“Oral administration of DORA-12 in aged PS19 mice increased non-REM and REM duration”
Animalsin aged PS19 mice
The Journal of neuroscience : the official journal of the Society for Neuroscience