Cell Stem Cell
Gene silencing lasts and partly reverses in human blood stem cells
Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice.Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice.
Human cell studyInterventions
Who was studiedPrimary human hematopoietic stem cells, 4 months
What changedITGB3 silencing persisted for 4 months after transplantation and partly reversed with targeted demethylation
The catchSilencing stability after transplantation was followed for only 4 months