Digital cognitive intervention

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: J. Willard and Alice S. Marriott Foundation and 5 more

Human trial1

Outcomes

Cognitive function

upin humans1

1 study

Digital cognitive intervention improves cognitive function in humans.
“Significant improvements were observed in depression, anxiety, everyday functioning, and cognitive performance (set-shifting and verbal fluency).”
Human trialPASC neurocognitive symptoms; before-and-after comparison without a control groupneuroscience-based6 weeksn = 39
Acceptability, Feasibility, and Preliminary Efficacy of a Digital Cognitive Intervention for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Older Adults
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry18 Sep 2026

Everyday functioning

upin humans1

1 study

Digital cognitive intervention improves everyday functioning in humans.
“Significant improvements were observed in depression, anxiety, everyday functioning, and cognitive performance (set-shifting and verbal fluency).”
Human trialPASC neurocognitive symptoms; before-and-after comparison without a control groupneuroscience-based6 weeksn = 39
Acceptability, Feasibility, and Preliminary Efficacy of a Digital Cognitive Intervention for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Older Adults
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry18 Sep 2026

Anxiety

downin humans1

1 study

Digital cognitive intervention decreases anxiety in humans.
“Significant improvements were observed in depression, anxiety, everyday functioning, and cognitive performance (set-shifting and verbal fluency).”
Human trialPASC neurocognitive symptoms; before-and-after comparison without a control groupneuroscience-based6 weeksn = 39
Acceptability, Feasibility, and Preliminary Efficacy of a Digital Cognitive Intervention for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Older Adults
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry18 Sep 2026