Current neighborhood deprivation

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans1

Outcomes

Spatial abilities

downin humans1

1 study

Current neighborhood deprivation impairs spatial abilities in humans (B = -0.05, SE = 0.02, p = 0.04).
“Current ADI was independently associated with lower spatial functioning, even after adjusting for early‐life ADI (B = ‐0.05, SE = 0.02, p = 0.04).”
Humansadjusting for early‐life ADI, age, sex, race, adoptive status, and APOE genotypen = 1,141
Associations Between Early/Current Neighborhood Deprivation and Midlife Cognitive Functioning: Results from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife)
AAIC 2025 abstract23 Dec 2025

Perceptual speed

downin humans1

1 study

Current neighborhood deprivation impairs perceptual speed in humans (B = -0.06, SE = 0.03, p = 0.03).
“current ADI (B = ‐0.06, SE = 0.03, p = 0.03) were each independently associated with poorer processing speed”
Humansadjusted for age, sex, race, adoptive status, and APOE genotypen = 1,141
Associations Between Early/Current Neighborhood Deprivation and Midlife Cognitive Functioning: Results from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife)
AAIC 2025 abstract23 Dec 2025

Latest

1 in 12 months

AAIC 2025 Abstract23 Dec

Associations Between Early/Current Neighborhood Deprivation and Midlife Cognitive Functioning: Results from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife)

Cohort study of 1,141 peoplePopulations

Paper

Current neighborhood deprivation

Outcomes

Latest

Associations Between Early/Current Neighborhood Deprivation and Midlife Cognitive Functioning: Results from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife)

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