Culturing elevated numbers of candidate HSCs

Culturing elevated numbers of candidate HSCs improves lymphopoiesis in cells.

“While in vitro activation fails to rescue lymphoid differentiation from most aged HSCs, robust lymphopoiesis can be achieved by culturing elevated numbers of candidate HSCs.”

Cellsin vitro culture of elevated numbers of candidate HSCs

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

Cell reports·Mar 23, 2023