Contact lenses
2 papers4 findings
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Humans2
Outcomes
4Angiogenesis
upin humans1
1 study
Angiogenesis
upin humans1
Contact lenses increase angiogenesis in humans.
“Moreover, most typical angiogenesis- and neurodegeneration-related genes showed significantly higher expression levels in the corneal epithelium after extended CL use.”
Humanscorneal epithelium
Investigative ophthalmology & visual scienceAug 1, 2025
Hypoxia and HIF signalling
upin humans1
1 study
Hypoxia and HIF signalling
upin humans1
Contact lenses increase hypoxia and HIF signalling in humans.
“Furthermore, we detected a significant upregulation of hypoxia-related genes in the corneal epithelium of CL wearers, accompanied by metabolic impairment and dysfunction.”
Humanscorneal epithelium
Investigative ophthalmology & visual scienceAug 1, 2025
Inflammation
upin humans1
1 study
Inflammation
upin humans1
Contact lenses increase inflammation in humans.
“Our analysis revealed a significant increase in epithelial keratinization and enhanced chronic inflammatory response in the CL group.”
Humanscorneal epithelium
Investigative ophthalmology & visual scienceAug 1, 2025
Cellular senescence
upin humans1
1 study
Cellular senescence
upin humans1
Contact lenses increase cellular senescence in humans.
“All epithelial cell types exhibited elevated senescence scores following prolonged CL wear.”
Humanscorneal epithelium
Investigative ophthalmology & visual scienceAug 1, 2025
Latest
Investigative Ophthalmology & Visual Science
Single-Cell Transcriptomics Reveals Effects of Long-Term Contact Lens Wearing on the Human Corneal Epithelium
Cross-sectional study in peopleMechanisms
The British Journal of Ophthalmology
Longitudinal associations between self-reported vision impairment and all-cause mortality: a nationally representative cohort study among older Chinese adults
Cohort study of 15,808 peopleVision impairment