Combined functional and aerobic training + folic acid

Combined functional and aerobic training + folic acid has been studied in 1 paper since 2026: 1 trial in people; 1 in the past year. The newest story, Nov 10, 2026: “Exercise plus folic acid may improve metabolism in men with obesity”.

Intervention

1 paper studies it4 findingsUpdated

1 new paper in 30 daysSee all 1 papers on combined functional and aerobic training + folic acid

At a glance

The findings reach people, from one lab or study. 1 lab in 2 countries.

“Body weight and BMI decreased significantly only in the CTS group (P = 0.001).”
The effects of combined functional and aerobic training along with folic acid supplementation on serum levels of Isthmin-1, inflammatory markers and insulin resistance in men with obesityBMC sports science, medicine & rehabilitation2026doi:10.1186/s13102-026-01962-9

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.
  • 1 lab in 2 countries
  • Human trial1

Studies in people

1 study gave combined functional and aerobic training + folic acid to people and measured what changed.

What changedDesignPeopleSource

down: Decreases body weight

down: Decreases HOMA-IR

up: Increases Isthmin 1

Randomized trial12 weeks11 peopleMen23-32 yearsObesityBMC sports science, medicine & rehabilitation, Aug 12, 2026

What did studies of combined functional and aerobic training + folic acid find?

4

Studies of combined functional and aerobic training + folic acid measured 4 outcomes, among them inflammatory markers, Isthmin 1 and HOMA-IR.

Inflammatory markers

downin humans1

1 study
  1. Combined functional and aerobic training + folic acid decreases inflammatory markers in humans (obesity).

    “serum levels of MCP-1, TNF-α, and IL-6 decreased significantly in all three intervention groups (P = 0.001).”

    Human trialobesity500 μg folic acid daily12 weeksmalesn = 11

    Exercise plus folic acid may improve metabolism in men with obesity

    BMC sports science, medicine & rehabilitation

More on Inflammatory markers

Isthmin 1

upin humans1

1 study
  1. Combined functional and aerobic training + folic acid increases Isthmin 1 in humans (obesity).

    “Serum ISM1 levels increased significantly in both the CT and CTS groups (P < 0.05)”

    Human trialobesity500 μg folic acid daily12 weeksmalesn = 11

    Exercise plus folic acid may improve metabolism in men with obesity

    BMC sports science, medicine & rehabilitation

More on Isthmin 1

HOMA-IR

downin humans1

1 study
  1. Combined functional and aerobic training + folic acid decreases HOMA-IR in humans (obesity).

    “all three active intervention groups (S, CT, and CTS) demonstrated significant reductions in fasting glucose, insulin, and HOMA-IR”

    Human trialobesity500 μg folic acid daily12 weeksmalesn = 11

    Exercise plus folic acid may improve metabolism in men with obesity

    BMC sports science, medicine & rehabilitation

More on HOMA-IR

Body weight

downin humans1

1 study
  1. Combined functional and aerobic training + folic acid decreases body weight in humans (obesity).

    “Body weight and BMI decreased significantly only in the CTS group (P = 0.001).”

    Human trialobesity500 μg folic acid daily12 weeksmalesn = 11

    Exercise plus folic acid may improve metabolism in men with obesity

    BMC sports science, medicine & rehabilitation

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 1Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months
BMC Sports Science, Medicine & Rehabilitation

Exercise plus folic acid may improve metabolism in men with obesity

A 12-week randomized trial in 44 men aged 23–32 found the largest improvements in blood sugar measures with combined exercise and supplementation.A 12-week randomized trial in 44 men aged 23–32 found the largest improvements in blood sugar measures with combined exercise and supplementation.

Randomized trial · 44 peopleFolic acid