Co-occurring social connection deficits
Intervention1 paper1 finding
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
Funder: National Institute on Aging
- Humans1
Outcomes
1DunedinPACE
upin humans1
1 study
DunedinPACE
upin humans1
Co-occurring social connection deficits increase DunedinPACE in humans (1.087, 95% CI = [1.066, 1.107] vs. 1.027, 95% CI = [1.019, 1.035]).
Humansin individuals who were socially isolated, lonely, and with low positive and high negative relationship qualityn = 2,343
Social Connection and Epigenetic Aging: Insights from DNA Methylation Clocks · Annals of the New York Academy of Sciences · 1 Sep 2026