Chronic loneliness

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Government of the United Kingdom and 2 more

Humans1

Associations

Mental wellbeing

downin humans1

1 study

Chronic loneliness is associated with mental wellbeing in humans.
“chronic loneliness was longitudinally associated with increased risks of worse general health, functional capacity, and mental wellbeing, and more unhealthy behaviours.”
Humansn = 4,090
Persistent loneliness linked to poorer health in older adults
Nature communications11 Sep 2026

Functional capacity

downin humans1

1 study

Chronic loneliness is associated with functional capacity in humans.
“chronic loneliness was longitudinally associated with increased risks of worse general health, functional capacity, and mental wellbeing, and more unhealthy behaviours.”
Humansn = 4,090
Persistent loneliness linked to poorer health in older adults
Nature communications11 Sep 2026

General health

downin humans1

1 study

Chronic loneliness is associated with general health in humans.
“chronic loneliness was longitudinally associated with increased risks of worse general health, functional capacity, and mental wellbeing, and more unhealthy behaviours.”
Humansn = 4,090
Persistent loneliness linked to poorer health in older adults
Nature communications11 Sep 2026

Latest

1 in 12 months

Nature Communications2 h

Persistent loneliness linked to poorer health in older adults

An observational study of 4,090 older adults linked persistent loneliness to poorer physical and mental health and more unhealthy behaviours.An observational study of 4,090 older adults linked persistent loneliness to poorer physical and mental health and more unhealthy behaviours.

Cohort study of 4,090 peoplePopulations

Paper

Chronic loneliness

Associations

Latest

Persistent loneliness linked to poorer health in older adults

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