CHIR99021/BMP4/Activin A/IWP2 cocktail
CHIR99021/BMP4/Activin A/IWP2 cocktail has been studied in 1 paper since 2026: none in people yet, 1 in cells; 1 in the past year. No study of it in people or animals has been published yet. The newest paper, Mar 23, 2026: “Refining fibroblast-to-cardiomyocyte transdifferentiation protocols to explore emergent self-organization in cardiac cultures”.
1 paper studies it3 findingsUpdated
See all 1 papers on CHIR99021/BMP4/Activin A/IWP2 cocktail
At a glance
The findings reach cells, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Ministry of Health of the Russian Federation and 2 more
- Cells1
What did studies of CHIR99021/BMP4/Activin A/IWP2 cocktail find?
3Studies of CHIR99021/BMP4/Activin A/IWP2 cocktail measured 3 outcomes: cardiac tissue conductivity, electrical excitability and α-actinin expression.
Cardiac tissue conductivity
upin cells1
1 study
Cardiac tissue conductivity
upin cells1
CHIR99021/BMP4/Activin A/IWP2 cocktail increases cardiac tissue conductivity in cells (partial reprogramming of fibroblasts into cardiac cells).
“This level of partial reprogramming of fibroblast cells into cardiac cells is sufficient to restore cardiac tissue conductivity”
Cellspartial reprogramming of fibroblasts into cardiac cellsfour-component cocktailcardiac tissue
PloS one
Electrical excitability
upin cells1
1 study
Electrical excitability
upin cells1
CHIR99021/BMP4/Activin A/IWP2 cocktail induces electrical excitability in cells.
“The use of the developed four-component protocol enables the generation of cells with electrical excitability and key cardiomyocyte markers”
Cellsfour-component cocktail
PloS one
α-actinin expression
upin cells1
1 study
α-actinin expression
upin cells1
CHIR99021/BMP4/Activin A/IWP2 cocktail induces α-actinin expression in cells (56-83% of cells).
“as evidenced by 56-83% of cells expressing α-actinin”
Cellsfour-component cocktail
PloS one