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Taurine + carnitine

Intervention

1 paper3 findings

PubChem 1123PubChem 288ChEBI 15891ChEBI 17126

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

3

Cardiovascular drug discontinuation

upin dogs1

1 study

  1. Taurine + carnitine induces cardiovascular drug discontinuation in dogs (All dogs successfully weaned off cardiovascular drugs).

    “All dogs were successfully weaned off furosemide, an angiotensin converting enzyme inhibitor, and digoxin once an echocardiographic response was identified.”

    Animalsafter an echocardiographic response to supplementation in American Cocker Spaniels with dilated cardiomyopathyn = 11

    Results of the multicenter spaniel trial (MUST): taurine- and carnitine-responsive dilated cardiomyopathy in American cocker spaniels with decreased plasma taurine concentration

    Journal of veterinary internal medicine1 Jan 1997

Shortening fraction

upin dogs1

1 study

  1. Taurine + carnitine increases shortening fraction in dogs.

    “Shortening fraction increased significantly but not into the normal range.”

    AnimalsAmerican Cocker Spaniels with dilated cardiomyopathy and decreased plasma taurineheartn = 11

    Results of the multicenter spaniel trial (MUST): taurine- and carnitine-responsive dilated cardiomyopathy in American cocker spaniels with decreased plasma taurine concentration

    Journal of veterinary internal medicine1 Jan 1997

Left ventricular end-diastolic and end-systolic diameters

downin dogs1

1 study

  1. Taurine + carnitine decreases left ventricular end-diastolic and end-systolic diameters in dogs.

    “During supplementation, left ventricular end-diastolic and end-systolic diameters, and mitral valve E point-to-septal separation decreased significantly in both groups.”

    AnimalsAmerican Cocker Spaniels with dilated cardiomyopathy and decreased plasma taurineheartn = 11

    Results of the multicenter spaniel trial (MUST): taurine- and carnitine-responsive dilated cardiomyopathy in American cocker spaniels with decreased plasma taurine concentration

    Journal of veterinary internal medicine1 Jan 1997

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