CA1 and prosubiculum tau-pet roi
1 paper3 findings
- 1 lab in 1 country
- Humans1
Outcomes
3CA1-specific tau signal detection
upin humans1
1 study
CA1-specific tau signal detection
upin humans1
CA1 and prosubiculum tau-pet roi improves CA1-specific tau signal detection in humans.
“Seven other discordant cases were considered hippocampal‐sparing using the whole hippocampus scheme despite showing significant tau signal specifically in CA1. The CA1 and prosubiculum ROI was able to capture this signal”
Humanstau-PET imagingCA1
Refining early tau‐PET staging using CA1 and prosubiculum rather than the whole hippocampus
AAIC 2025 abstract23 Dec 2025
Choroid plexus off-target binding false positives
downin humans1
1 study
Choroid plexus off-target binding false positives
downin humans1
CA1 and prosubiculum tau-pet roi decreases choroid plexus off-target binding false positives in humans.
“Visual inspection confirmed these as false positives driven by off‐target binding in the choroid plexus. This off‐target binding did not affect the CA1 and prosubiculum ROI”
Humanstau-PET quantificationhippocampus
Refining early tau‐PET staging using CA1 and prosubiculum rather than the whole hippocampus
AAIC 2025 abstract23 Dec 2025
Discordant staging cases
downin humans1
1 study
Discordant staging cases
downin humans1
CA1 and prosubiculum tau-pet roi decreases discordant staging cases in humans (-65% (15 [1.78%] vs 44 [5.22%])).
“The CA1 and prosubiculum staging resulted in 15 (1.78%) discordant cases, 65% less than the whole hippocampus staging (44, 5.22%).”
Humanstau-PET staginghippocampusn = 432
Refining early tau‐PET staging using CA1 and prosubiculum rather than the whole hippocampus
AAIC 2025 abstract23 Dec 2025