AgingResearch.NewsJoin free

Blood pressure fluctuation

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Institute on Aging
  • Humans1

Outcomes

1

White matter hyperintensity volume

upin humans1

1 study

  1. Blood pressure fluctuation increases white matter hyperintensity volume in humans (F(3,610) = 3.52, P = .02).

    “White matter hyperintensity volume increased across the 4 groups in a linear manner, with the lowest WMH volume in the lowest mean/lowest SD group and the highest WMH volume in the highest mean/highest SD group”

    Humansacross groups of mean blood pressure and fluctuationbrain

    Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort

    Archives of neurology1 May 2010

More on White matter hyperintensity volume

Associations

1

Brain infarction

upin humans1

1 study

  1. Blood pressure fluctuation raises the risk of brain infarction in humans (from 22% to 41%, P for trend = .004).

    “Frequency of infarction also increased monotonically across groups (from 22% to 41%, P for trend = .004).”

    Humansbrainn = 686

    Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort

    Archives of neurology1 May 2010

More on Brain infarction

Latest

Related