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Birth cohort

Exposure

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Outcomes

4

Mental health

downin humans1

1 study

  1. Birth cohort impairs mental health in humans (η2=0.008).

    “mental health assessed by WHO-5 was lower in later cohort(η2=0.008)”

    Humansborn 1951-1954 vs 1938-1941

    COMPARISON OF HEALTH OUTCOMES AMONG TWO SEPTUAGENARIAN COHORTS A DECADE APART IN JAPAN

    GSA 2024 abstract31 Dec 2024

Cognitive function

upin humans1+7.9%

1 study

  1. Birth cohort improves cognitive function in humans (+7.93%).

    “the later cohort showed 7.93% higher MOCA-J score”

    Humansborn 1951-1954 vs 1938-1941

    COMPARISON OF HEALTH OUTCOMES AMONG TWO SEPTUAGENARIAN COHORTS A DECADE APART IN JAPAN

    GSA 2024 abstract31 Dec 2024

Gait speed

upin humans1+14%

1 study

  1. Birth cohort improves gait speed in humans (+13.65%).

    “13.65% higher gait speed”

    Humansborn 1951-1954 vs 1938-1941

    COMPARISON OF HEALTH OUTCOMES AMONG TWO SEPTUAGENARIAN COHORTS A DECADE APART IN JAPAN

    GSA 2024 abstract31 Dec 2024

Grip strength

upin humans1+21%

1 study

  1. Birth cohort increases grip strength in humans (+21.08%).

    “the later cohort showed 21.08% higher grip strength”

    Humansborn 1951-1954 vs 1938-1941

    COMPARISON OF HEALTH OUTCOMES AMONG TWO SEPTUAGENARIAN COHORTS A DECADE APART IN JAPAN

    GSA 2024 abstract31 Dec 2024

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