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Beta-hydroxy-beta-methylbutyrate + l-arginine + l-lysine

Intervention

1 paper3 findings

PubChem 6950804PubChem 6322PubChem 5962ChEBI 82957ChEBI 16467ChEBI 18019

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Institute on Aging
  • 3 of 3 findings with company ties
  • Human trial1

Outcomes

3

Amino acid metabolism

upin humans1

1 study

  1. Beta-hydroxy-beta-methylbutyrate + l-arginine + l-lysine increases amino acid metabolism in humans (increased 8% and 12% vs decreased 11% and 9% (P<.01)).

    “The rates of protein turnover were significantly increased 8% and 12% in the HMB/Arg/Lys-supplemented group while rates of protein turnover decreased 11% and 9% in the control-supplemented subjects (P<.01)”

    Human trial1 year

    Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine

    JPEN. Journal of parenteral and enteral nutrition1 Jan 2009

More on Amino acid metabolism

Lean tissue mass

upin humans1

1 study

  1. Beta-hydroxy-beta-methylbutyrate + l-arginine + l-lysine increases lean tissue mass in humans (+1.2% (P=.05)).

    “and lean mass (DXA) by 1.2% (P=.05).”

    Human trial1 year

    Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine

    JPEN. Journal of parenteral and enteral nutrition1 Jan 2009

Body cell mass

upin humans1

1 study

  1. Beta-hydroxy-beta-methylbutyrate + l-arginine + l-lysine increases body cell mass in humans (+1.6% (P=.002)).

    “Compared with control, HMB/Arg/Lys increased body cell mass (BIA) by 1.6% (P=.002)”

    Human trial1 year

    Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine

    JPEN. Journal of parenteral and enteral nutrition1 Jan 2009

More on Body cell mass

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