Berberine + white mulberry leaf extract + chromium picolinate
Intervention1 paper4 findings
- Human trial1
Outcomes
4Insulin sensitivity
upin humans1Moderate certainty
1 study
Insulin sensitivity
upin humans1Moderate certainty
Berberine + white mulberry leaf extract + chromium picolinate improves insulin sensitivity in humans (28% greater improvement (adjusted geometric mean ratio 1.28)).
Human trialobesity12 weeksn = 93
Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial · Nutrients · 27 Aug 2026
Visceral fat rating
downin humans1Moderate certainty
1 study
Visceral fat rating
downin humans1Moderate certainty
Berberine + white mulberry leaf extract + chromium picolinate decreases visceral fat rating in humans (-0.92 units).
Human trialobesity12 weeksn = 93
Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial · Nutrients · 27 Aug 2026
Total body fat mass
downin humans1Moderate certainty
1 study
Total body fat mass
downin humans1Moderate certainty
Berberine + white mulberry leaf extract + chromium picolinate decreases total body fat mass in humans (-2.35 kg).
Human trialobesity12 weeksn = 93
Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial · Nutrients · 27 Aug 2026
Body mass index
downin humans1Moderate certainty
1 study
Body mass index
downin humans1Moderate certainty
Berberine + white mulberry leaf extract + chromium picolinate decreases body mass index in humans (-1.24 kg per square meter).
Human trialobesity12 weeksn = 93
Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial · Nutrients · 27 Aug 2026