BDA-410

1. BDA-410 improves muscle force generation in mice.

   “improved muscle force generation in sedentary old mice.”

   Animalssedentary miceskeletal muscle

   Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice

   Aging cell·Feb 19, 2016

1. BDA-410 increases CaV1.1 expression in mice.

   “prevented TnT3 fragmentation, and Cacna1s and Cav1.1 downregulation”

   Animalssedentary miceskeletal muscle

   Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice

   Aging cell·Feb 19, 2016

More on CaV1.1 expression

1. BDA-410 prevents TnT3 fragmentation in mice.

   “Systemic administration of BDA-410, a specific calpain inhibitor, prevented TnT3 fragmentation”

   Animalssedentary miceskeletal muscle

   Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice

   Aging cell·Feb 19, 2016

More on TnT3 fragmentation