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Basic fibroblast growth factor + carboxymethyl cellulose-pyrogallol hydrogel

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Korea Health Industry Development Institute and 6 more
  • Animals1

Outcomes

3

Angiogenesis

upin rats1

1 study

  1. Basic fibroblast growth factor + carboxymethyl cellulose-pyrogallol hydrogel increases angiogenesis in rats.

    “showing increased hyaluronic acids layer and muscle density, enhanced angiogenesis, and modulated immunogenicity.”

    Animalsaged vocal foldsvocal fold

    Tunicate-Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age-Associated Vocal Fold Atrophy

    Advanced healthcare materials28 Oct 2025

More on Angiogenesis

Vocal fold function

upin rats1

1 study

  1. Basic fibroblast growth factor + carboxymethyl cellulose-pyrogallol hydrogel improves vocal fold function in rats.

    “bFGF-loaded CMC-PG hydrogel facilitates functional restoration of the aged vocal folds.”

    Animalsaged vocal foldsvocal fold

    Tunicate-Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age-Associated Vocal Fold Atrophy

    Advanced healthcare materials28 Oct 2025

Lamina propria and muscle layer regeneration

upin rats1

1 study

  1. Basic fibroblast growth factor + carboxymethyl cellulose-pyrogallol hydrogel improves lamina propria and muscle layer regeneration in rats.

    “Injection of CMC-PG hydrogel encapsulating basic fibroblast growth factor (bFGF) regenerates both the lamina propria and the muscle layer in the vocal folds of an aged rat model”

    Animalsaged vocal foldsvocal fold

    Tunicate-Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age-Associated Vocal Fold Atrophy

    Advanced healthcare materials28 Oct 2025

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