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Audiogenic kindling

Intervention

2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country

Outcomes

2

Hippocampal glutamatergic system proteins

downin rats1

1 study

  1. Audiogenic kindling decreases hippocampal glutamatergic system proteins in rats.

    “These alterations were accompanied by a decrease in glutaminase, vesicular glutamate transporters, and AMPA receptor subunits”

    AnimalsKrushinsky-Molodkina audiogenic rats; glutaminase, vesicular glutamate transporters and AMPA receptor subunitshippocampus14 days

    Accelerated Establishment of Limbic Seizures in Aging Krushinsky-Molodkina Audiogenic Rats Is Associated With Neurodegeneration and Downregulation of the Glutamatergic Transmission in the Hippocampus

    Developmental neurobiology30 Jan 2026

More on Hippocampal glutamatergic system proteins

Hippocampal cell loss

upin rats1

1 study

  1. Audiogenic kindling increases hippocampal cell loss in rats.

    “a comparison of aging KM rats, exposed to 14-day kindling, with non-stimulated (naïve) controls of the same age revealed seizure-induced loss of the hippocampal cells.”

    AnimalsKrushinsky-Molodkina audiogenic rats compared with non-stimulated controls of the same agehippocampus14 days

    Accelerated Establishment of Limbic Seizures in Aging Krushinsky-Molodkina Audiogenic Rats Is Associated With Neurodegeneration and Downregulation of the Glutamatergic Transmission in the Hippocampus

    Developmental neurobiology30 Jan 2026

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