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ATN-224

ATN-224 has been studied in 2 papers since 2023: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Feb 20, 2025: “Activity-based sensing reveals elevated labile copper promotes liver aging via hepatic ALDH1A1 depletion”.

Intervention

2 papers study it2 findingsUpdated

PubChem

See all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Alfred P. Sloan Foundation and 8 more
  • Animals2

What did studies of ATN-224 find?

2

Studies of ATN-224 measured 2 outcomes; the most studied are ALDH1A1 (1 study) and hepatic stem cell (1).

ALDH1A1

upin mice1

1 study

  1. ATN-224 increases ALDH1A1 in mice.

    “treatment improves Cu homeostasis and preserves ALDH1A1 activity”

    Animalsliver

    Activity-based sensing reveals elevated labile copper promotes liver aging via hepatic ALDH1A1 depletion

    Nature communications

More on ALDH1A1

Hepatic stem cell

upin mice1

1 study

  1. ATN-224 improves hepatic stem cell in mice.

    “treatment restores Cu homeostasis which may have a hSC-sparing effect to delay the onset of liver aging”

    Animalsliver

    Activity-based sensing reveals elevated labile copper promotes liver aging via hepatic stem cell depletion

    ChemRxivPreprint

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