Beta-hydroxy-beta-methylbutyrate + arginine + lysine

1 paper4 findings

PubChem 6950804 PubChem 6322 PubChem 5962 ChEBI 82957 ChEBI 16467 ChEBI 18019

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Center for Research Resources and 1 more

Human trial1

Outcomes

protein synthesis

upin humans1

1 study

Beta-hydroxy-beta-methylbutyrate + arginine + lysine increases protein synthesis in humans (approximately 20% (P = 0.03)).
“Whole-body protein synthesis, estimated with the (15)N-glycine tracer technique over a 24-h free-living period, increased approximately 20% in the experimental treatment group as opposed to the placebo group (P = 0.03).”
Human trial12 wkfemales
Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
Nutrition (Burbank, Los Angeles County, Calif.)1 May 2004

Leg strength

upin humans1

1 study

Beta-hydroxy-beta-methylbutyrate + arginine + lysine improves leg strength in humans (P < 0.05).
“The improvement in functionality also was reflected by increased limb circumference, leg strength, and handgrip strength (all P < 0.05)”
Human trial12 wkfemales
Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
Nutrition (Burbank, Los Angeles County, Calif.)1 May 2004

Handgrip strength

upin humans1

1 study

Beta-hydroxy-beta-methylbutyrate + arginine + lysine improves handgrip strength in humans (P < 0.05).
“The improvement in functionality also was reflected by increased limb circumference, leg strength, and handgrip strength (all P < 0.05)”
Human trial12 wkfemales
Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
Nutrition (Burbank, Los Angeles County, Calif.)1 May 2004

Timed Up and Go

upin humans1

1 study

Beta-hydroxy-beta-methylbutyrate + arginine + lysine improves timed Up and Go in humans (17% improvement (-2.3 +/- 0.5 s vs 0.0 +/- 0.5 s)).
“After 12 wk, there was a 17% improvement in the "get-up-and-go" functionality test in the experimental group (-2.3 +/- 0.5 s) but no change in the placebo group”
Human trial12 wkfemales
Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
Nutrition (Burbank, Los Angeles County, Calif.)1 May 2004