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Anticholinergic medication burden

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 2 countries
  • Funder: Ministero della Salute
  • Humans1

Associations

1

Hospitalization or all-cause mortality

upin humans1HR 1.46

1 study

  1. Anticholinergic medication burden raises the risk of hospitalization or all-cause mortality in humans (HR 1.46, 95% CI 1.12-1.90).

    “compared with participants with an ACB of 0, those with an ACB of 1 [HR 1.46; 95% confidence interval (CI) 1.12-1.90] and ABC of 2+ (HR 1.41; 95% CI 1.11-1.79) presented an increased risk”

    Humans5 years72% femalessn = 3,761

    Anticholinergic Medication Burden and 5-Year Risk of Hospitalization and Death in Nursing Home Elderly Residents With Coronary Artery Disease

    Journal of the American Medical Directors Association31 Aug 2016

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