Anti-mpl neutralizing antibody

Intervention1 paper2 findings

Animals1

Outcomes

2

Coronary microvascular density

upin mice1Very low certainty

1 study

Anti-mpl neutralizing antibody increases coronary microvascular density in mice.
Animalsin mice with JAK2V617F-mutant hematopoiesis on high-fat/high-cholesterol diet
Targeting Thrombopoietin/MPL Signaling to Mitigate JAK2V617F-Driven Cardiac Microvascular Disease · Arteriosclerosis, thrombosis, and vascular biology · 3 Sep 2026

Cardiovascular pathology

downin mice1Very low certainty

1 study

Anti-mpl neutralizing antibody decreases cardiovascular pathology in mice.
Animalsin mice with JAK2V617F-mutant hematopoiesis on high-fat/high-cholesterol diet
Targeting Thrombopoietin/MPL Signaling to Mitigate JAK2V617F-Driven Cardiac Microvascular Disease · Arteriosclerosis, thrombosis, and vascular biology · 3 Sep 2026

Latest

1

Arteriosclerosis, Thrombosis, and Vascular BiologyAnimals3 Sep

Targeting Thrombopoietin/MPL Signaling to Mitigate JAK2V617F-Driven Cardiac Microvascular Disease

JAK–STAT signalling