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ANTI-CD49D antibody

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 5 more
  • Animals1

Outcomes

3

CD8-positive T cells

downin mice1

1 study

  1. ANTI-CD49D antibody decreases CD8-positive T cells in mice.

    “aCD49d Ab reduces CD8+ T cells exhibiting higher effector status, leading to reduced clonal expansion in aged, but not young, mouse brains with chronic TBI.”

    Animalschronic TBIbrain

    Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8⁺ T-cell cytotoxicity after traumatic brain injury

    Journal of neuroinflammationOct 19, 2024

More on CD8-positive T cells

Cell killing (cytotoxicity)

downin mice1

1 study

  1. ANTI-CD49D antibody decreases cell killing (cytotoxicity) in mice.

    “remediation of overall CD8+ T cell cytotoxicity.”

    Animalslong-term post-TBIbrain

    Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8⁺ T-cell cytotoxicity after traumatic brain injury

    Journal of neuroinflammationOct 19, 2024

More on Cell killing (cytotoxicity)

Inflammation

downin mice1

1 study

  1. ANTI-CD49D antibody decreases inflammation in mice.

    “aCD49d Ab attenuates this response along with a T helper (Th)1/Th17 immunological shift and remediation of overall CD8+ T cell cytotoxicity.”

    Animalslong-term post-TBIbrain

    Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8⁺ T-cell cytotoxicity after traumatic brain injury

    Journal of neuroinflammationOct 19, 2024

More on Inflammation

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