Ambulatory activity

3 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: European Commission and 7 more

Human trial2
Humans1

Associations

Fall risk

upin humans2

2 studies

Ambulatory activity raises the risk of fall risk in humans (∼23-24% increased relative fall risk, ∼6% increase in injury risk).
“Moderate‐capacity participants had a ∼23‐24% increased relative fall risk between activity levels, with only a ∼6% increase in injury risk.”
Humansin aged residential care residents with moderate physical capacityn = 71
Rethinking the role of ambulatory activity in falls risk in aged residential care: influence of physical capacity and cognitive impairment
AAIC 2025 abstract25 Dec 2025
Ambulatory activity raises the risk of fall risk in humans (p = 0.046).
“Higher daily step count were linked with increased falls rate ( p = 0.046), with a significant interaction ( p = 0.036): the Moderate Group showed a positive association between steps and falls”
HumansModerate physical capacityn = 71
Rethinking the role of ambulatory activity in falls risk in aged residential care: influence of physical capacity and cognitive impairment
AAIC 2025 abstract23 Dec 2025

Falls rate

upin humans1

1 study

Ambulatory activity is associated with falls rate in humans (p = 0.046).
“Higher daily step count were linked with increased falls rate ( p = 0.046)”
Humansin aged residential care residentsn = 281
Rethinking the role of ambulatory activity in falls risk in aged residential care: influence of physical capacity and cognitive impairment
AAIC 2025 abstract25 Dec 2025

Fall-related injuries

upin humans1

1 study

Ambulatory activity raises the risk of fall-related injuries in humans (∼6% higher relative risk).
“The Moderate group had a ∼23%-24% and ∼6% higher relative risk of falls and fall-related injuries, respectively, with higher activity”
Humansmoderate functional capacity
Rethinking the relationship between ambulatory activity and falls in long-term care: risk versus reward
The journals of gerontology. Series A, Biological sciences and medical sciences8 Sep 2025

Falls

upin humans1

1 study

Ambulatory activity raises the risk of falls in humans (∼23%-24% higher relative risk).
“The Moderate group had a ∼23%-24% and ∼6% higher relative risk of falls and fall-related injuries, respectively, with higher activity”
Humansmoderate functional capacity
Rethinking the relationship between ambulatory activity and falls in long-term care: risk versus reward
The journals of gerontology. Series A, Biological sciences and medical sciences8 Sep 2025